Differential activation of the rat hippocampus and perirhinal cortex by novel visual stimuli and a novel environment

Zhu, X. O., McCabe, B. J., Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 and Brown, M. W. 1997. Differential activation of the rat hippocampus and perirhinal cortex by novel visual stimuli and a novel environment. Neuroscience Letters 229 (2) , pp. 141-143. 10.1016/S0304-3940(97)00437-0

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Abstract

Two groups of rats were shown individual novel visual objects. One group had been familiarised to the environmental context within which the objects were shown, the other experienced the situation for the first time. The activation of neurones in perirhinal cortex and the hippocampal formation was determined by counts of nuclei stained for products of the immediate early gene c-fos. The ratio of counts in the hippocampal formation to that in perirhinal cortex was compared for the two groups: the ratio was significantly higher (4.2:1) in the group experiencing the environment for the first time. Thus, whereas perirhinal neurones are activated by novel rather than familiar objects, hippocampal neurones are preferentially activated by a novel rather than a familiar environment.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Learning; Memory; Recognition; Priming; Visual; Immediate early genes; c-Fos; Amnesia; Rhinal cortex; Hippocampus; Rat
Publisher:	Elsevier
ISSN:	0304-3940
Last Modified:	21 Oct 2022 08:58
URI:	https://orca.cardiff.ac.uk/id/eprint/34940

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