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Diurnal Variation of Central Corneal Thickness and Goldmann Applanation Tonometry Estimates of Intraocular Pressure

Hamilton-Maxwell, Kirsten E. ORCID:, Pye, D. C., Aggarwala, S., Evian, S., Khosla, J. and Perera, R. 2007. Diurnal Variation of Central Corneal Thickness and Goldmann Applanation Tonometry Estimates of Intraocular Pressure. Journal of Glaucoma 16 (1) , pp. 29-35. 10.1097/IJG.0b013e31802b350f

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URPOSE: To determine whether there is a temporal relationship between the diurnal variation of central corneal thickness (CCT) and intraocular pressure (IOP) by Goldmann applanation tonometry in young normal human participants in vivo. METHODS: Twenty-five eyes of 25 young healthy normal participants were examined in a prospective observational cross-sectional study. IOP, CCT and corneal curvature were measured using standard clinical techniques over a 24-hour period, and the temporal interrelationships between these parameters were examined. RESULTS: The overnight change in IOP measured by Goldmann tonometry was 3.1+/-2.4 mm Hg (P<0.001), CCT was 20.1+/-10.9 mum (P=0.016), with no statistical change in central corneal curvature (0.05 mm, P=0.477, paired t test with Bonferroni correction). Both IOP and CCT were highest on awakening at 7:00 then dropped rapidly to baseline levels by 9:00 (linear mixed models), and these two parameters were highly correlated (r=0.978, P<0.001). After 9:00, there was no correlation between these parameters (r=-0.453, P=0.260). CONCLUSIONS: The results of this study have highlighted a potential link between the diurnal variation of CCT and the accuracy of Goldmann tonometry estimates of IOP during the first 2 hours after awakening. Clinicians should be wary of using Goldmann tonometry to estimate IOP until the overnight increase in CCT has resolved.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Uncontrolled Keywords: diurnal variation, intraocular pressure, corneal thickness, tonometry
Publisher: Lippincott Williams & Wilkins
ISSN: 1057-0829
Last Modified: 21 Oct 2022 09:09

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