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Cognitive functions and corticostriatal circuits: insights from Huntington's disease

Lawrence, Andrew David ORCID:, Sahakian, Barbara J. and Robbins, Trevor W. 1998. Cognitive functions and corticostriatal circuits: insights from Huntington's disease. Trends in Cognitive Sciences 2 (10) , pp. 379-388. 10.1016/S1364-6613(98)01231-5

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The basic mechanisms of information processing by corticostriatal circuits are currently a matter of intense debate amongst cognitive scientists. Huntington's disease, an autosomal-dominant neurogenetic disorder characterized clinically by a triad of motor, cognitive, and affective disturbance, is associated with neuronal loss within corticostriatal circuits, and as such provides a valuable model for understanding the role of these circuits in normal behaviour, and their disruption in disease. We review findings from our studies of the breakdown of cognition in Huntington's disease, with a particular emphasis on executive functions and visual recognition memory. We show that Huntington's disease patients exhibit a neuropsychological profile that shows a discernible pattern of progression with advancing disease, and appears to result from a breakdown in the mechanisms of response selection. These findings are consistent with recent computational models that suggest that corticostriatal circuits compute the patterns of sensory input and response output which are of behavioural significance within a particular environmental context.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Huntington's disease; basal ganglia; striatum; frontal-executive function; dopamine; attention
Publisher: Elsevier
ISSN: 1364-6613
Last Modified: 21 Oct 2022 09:10

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