Treatment of morning migraine. Clinical and biokinetic correlation of programmed-release dihydroergotamine

Aylward, Mansel, Chazot, G., Maddock, J. and Schott, B. 1984. Treatment of morning migraine. Clinical and biokinetic correlation of programmed-release dihydroergotamine. La Presse Médicale 13 (26) , pp. 1617-1619.

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Abstract

The authors have tested a new preparation of dihydroergotamine (microgranules in a capsule) by comparing the clinical results obtained in 30 patients suffering from morning migraine with the plasma levels of the active substance measured in 8 healthy subjects. The microgranules were administered in doses of 30 mg/24 hours and compared with a similar dose of a dihydroergotamine solution. The close correlation observed between sustained plasma levels and prolonged therapeutic effects indicates a truly programmed delivery of dihydroergotamine by the microgranule preparation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Language other than English:	French
Publisher:	Elsevier
ISSN:	0755-4982
Last Modified:	04 Jun 2017 04:18
URI:	https://orca.cardiff.ac.uk/id/eprint/36486

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