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Treatment of rheumatoid arthritis with tolmetin: a comparison with alclofenac

Aylward, Mansel, Holly, F., Maddock, J. and Wheeldon, R. 1977. Treatment of rheumatoid arthritis with tolmetin: a comparison with alclofenac. Current Medical Research and Opinion 4 (10) , pp. 695-702. 10.1185/03007997609112004

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A double-blind between-patient trial over 6 weeks to compare the effects of 1.6 g tolmetin daily with 4 g alclofenac daily was completed by 37 out of 44 out-patients with rheumatoid arthritis. Tolmetin proved as effective as alclofenac in relieving pain and in reducing both the articular index score and the number of inflamed joints. However, alclofenac produced a significantly greater reduction in the duration of morning stiffness, which could have been related to the timing of the initial daily dose of tolmetin. Onset of fatigue was significantly improved by both drugs. Neither treatment group exhibited any significant changes in the serum levels of IgG, IgA, and IgM, nor in the latex and sheep-cell agglutination titres. Although neither drug gave rise to serious side-effects, 3 patients (2 on tolmetin, 1 on alclofenac) were withdrawn because of skin rash, 2 (on tolmetin)because of gastro-intestinal upsets, and I from each group because of lack of analgesic effect. Read More:

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: tolmetin, alclofenac, anti-inflammatory agents, arthritis, rheumatoid
Publisher: Informa Healthcare
ISSN: 0300-7995
Last Modified: 04 Jun 2017 04:18

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