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Long-term study of indomethacin and alclofenac in treatment of rheumatoid arthritis

Aylward, Mansel, Parker, R. J., Holly, F., Maddock, J. and Davies, D. B. 1975. Long-term study of indomethacin and alclofenac in treatment of rheumatoid arthritis. British Medical Journal 2 (5961) , pp. 7-9. 10.1136/bmj.2.5961.7

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Indomethacin and alclofenac were compared for 13 months under double-blind conditions in 109 patients with active, classical, or definite rheumatoid arthritis at a relatively early stage of the disease. Both indomethacin and alclofenac were clearly effective: most patients either improved or remained as well controlled as on entry. Alclofenac proved the more effective drug, however, producing a significantly greater reduction in morning stiffness, articular index, and erythrocyte sedimentation rate, and only in the alclofenac-treated group did functional capacity improve and latex-agglutination titres diminish. Comprehensive laborabory tests showed no significant deviation from normal which could have been attributed to either drug.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Additional Information: Pdf uploaded in accordance with publisher's policy at (accessed 26/02/2014)
Publisher: BMJ Publishing Group
ISSN: 0267-0623
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 04:19

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