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Clinical studies on alclofenac in the treatment of rheumatic diseases: a drug in question

Aylward, Mansel 1975. Clinical studies on alclofenac in the treatment of rheumatic diseases: a drug in question. Current Medical Research and Opinion 3 (5) , pp. 274-285. 10.1185/03007997509114778

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The potential advantage to patients with chronic rheumatic diseases of an effective, non-steroidal analgesic anti-inflammatory drug which causes insignificant gastric bleecling was a decisive factor leacling to the introduction of alclofenac. Short-term double-blind trials showed that alclofenac has analgesic / anti-inflammatory activities equivalent to phenylbutazone, indomethacin and aspirin, but superior to thefenemates and propionic acid derivatives. Long-term controlled studies, ranging from 5 months to 3½ years and using reliable, objective measures reveal, however, that patients with rheumatoid arthritis improve in functional status and graduate to less severe classes of disease activity, a phenomenon not observed with either indomethacin or aspirin administered to matched patients over the same periods of time. So far, clinical improvement on alclofenac has been matched only by treatment with gold, D-penicillamine and the immunosuppressive antiproliferative drugs. This clinical improvement on alclofenac is reflected in haemato-logical and serological indices, and research shows that alclofenac, like these other antirheumatoid drugs, has a pronounced effect upon the acute-phase protein response and the extent to which L-tryptophan is bound to plasma protein. The clinical data reviewed suggest that alclofenac represents an advance in the therapy of the rheumatic diseases.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: alclofenac, anti-inflammatory agents, arthritis, rheumatoid
Publisher: Informa Healthcare
ISSN: 0300-7995
Last Modified: 04 Jun 2017 04:19

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