Proceedings: plasma L-tryptophan concentrations in chronic rheumatic diseases and the effects of some antirheumatic drugs on the binding of the amino-acid to plasma proteins in vivo and in vitro

Aylward, Mansel and Maddock, J. 1974. Proceedings: plasma L-tryptophan concentrations in chronic rheumatic diseases and the effects of some antirheumatic drugs on the binding of the amino-acid to plasma proteins in vivo and in vitro. Rheumatology and Rehabilitation 13 (2) , pp. 62-74. 10.1093/rheumatology/13.2.62

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Abstract

L-TRYPTOPHAN may be used as a model endogenous molecule to study the binding characteristics of the plasma proteins of patients with connective-tissue diseases. A drug's ability to displace L-tryptophan from binding to human serum albumin may also represent a new in-vitro assay for screening drugs for potential anti-inflammatory activity. In patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis, antirheumatic drugs displace L-tryptophan from plasma proteins in vivo, whereas withdrawal of such therapy is associated with excessive binding of the amino-acid to plasma proteins. In children with Still's disease, virtually all plasma tryptophan exists in the protein-bound form, and protein-bound tryptophan is less easily displaced from Still's disease plasma than from healthy children's plasma by antirheumatic drugs in vitro. Results obtained with the novel in-vitro assay described indicate its greater sensitivity than the Mizushima test for screening antirheumatic agents.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Publisher:	Baillière Tindall
ISSN:	0300-3396
Last Modified:	04 Jun 2017 04:19
URI:	https://orca.cardiff.ac.uk/id/eprint/36648

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