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Optical imaging of intrinsic signals: recent developments in the methodology and its applications

Zapeda, A., Arias, C. and Sengpiel, Frank ORCID: 2004. Optical imaging of intrinsic signals: recent developments in the methodology and its applications. Journal of Neuroscience Methods 136 (1) , pp. 1-21. 10.1016/j.jneumeth.2004.02.025

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Since optical imaging (OI) of intrinsic signals was first developed in the 1980s, significant advances have been made regarding our understanding of the origins of the recorded signals. The technique has been refined and the range of its applications has been broadened considerably. Here we review recent developments in methodology and data analysis as well as the latest findings on how intrinsic signals are related to metabolic cost and electrophysiological activity in the brain. We give an overview of what optical imaging has contributed to our knowledge of the functional architecture of sensory cortices, their development and plasticity. Finally, we discuss the utility of OI for functional studies of the human brain as well as in animal models of neuropathology.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RE Ophthalmology
Uncontrolled Keywords: Optical imaging; Intrinsic signals; Event-related; Fourier analysis; Functional architecture; Development; Plasticity
Publisher: Elsevier
ISSN: 0165-0270
Last Modified: 21 Oct 2022 09:49

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