Immunogenicity and efficacy of an anthrax/plague DNA fusion vaccine in a mouse model

Albrecht, M. T., Eyles, J. E., Baillie, Les ORCID: https://orcid.org/0000-0002-8186-223X and Keane-Myers, A. M. 2012. Immunogenicity and efficacy of an anthrax/plague DNA fusion vaccine in a mouse model. FEMS Immunology & Medical Microbiology 65 (3) , pp. 505-509. 10.1111/j.1574-695X.2012.00974.x

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Abstract

The efficacy of multi-agent DNA vaccines consisting of a truncated gene encoding Bacillus anthracis lethal factor (LFn) fused to either Yersinia pestis V antigen (V) or Y. pestis F1 was evaluated. A/J mice were immunized by gene gun and developed predominantly IgG1 responses that were fully protective against a lethal aerosolized B. anthracis spore challenge but required the presence of an additional DNA vaccine expressing anthrax protective antigen to boost survival against aerosolized Y. pestis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	anthrax; plague; DNA vaccine
Publisher:	Wiley-Blackwell
ISSN:	1574-695X
Last Modified:	21 Oct 2022 10:34
URI:	https://orca.cardiff.ac.uk/id/eprint/40632

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