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Human γδ T-cell responses in infection and immunotherapy: Common mechanisms, common mediators?

Riganti, Chiara, Massaia, Massimo, Davey, Martin S. and Eberl, Matthias 2012. Human γδ T-cell responses in infection and immunotherapy: Common mechanisms, common mediators? European Journal of Immunology 42 (7) , pp. 1668-1676. 10.1002/eji.201242492

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Upon receiving the Nobel Prize in Physiology or Medicine in 1987, Susumu Tonegawa referred to the then recent discovery of the γδ T-cell receptor and stated that “while the function of the T cells bearing this receptor is currently unknown ( . . . ) these T cells may be involved in an entirely new aspect of immunity”. [Tonegawa, S., Scand. J. Immunol. 1993. 38: 303–319]. Twenty-five years of intense research later this ambivalent view still holds true. Immunologists now appreciate that γδ T cells indeed represent a highly intriguing “new aspect of immunity” that is unique and distinct from conventional lymphocytes, yet even scientists in the field still struggle to understand the molecular basis of γδ T-cell responses, especially with respect to the enigmaticmode of antigen recognition. Here, we portray the peculiar responsiveness of human Vγ9/Vδ2 T cells to microorganisms, tumor cells and aminobisphosphonates, in an attempt to integrate the corresponding — and at times confusing — findings into a “theory of everything” that may help explain how such diverse stimuli result in similar γδ T-cell responses via the recognition of soluble low molecular weight phosphoantigens.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > R Medicine (General)
Uncontrolled Keywords: Antigen presentation; Cancer immunotherapy; γδ T cells; Microbial infections; T-cell receptor
Publisher: John Wiley & Sons
ISSN: 0014-2980
Last Modified: 11 Sep 2020 08:39

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