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Association at SYNE1 in both bipolar disorder and recurrent major depression

Green, Elaine Karen, Grozeva, Detelina ORCID:, Forty, Elizabeth, Gordon-Smith, K., Russell, Elen, Farmer, A., Hamshere, Marian Lindsay ORCID:, Jones, Ian Richard ORCID:, Jones, L., McGuffin, P., Moran, J. L., Purcell, S., Sklar, P., Owen, Michael John ORCID:, O'Donovan, Michael Conlon ORCID: and Craddock, Nicholas John ORCID: 2013. Association at SYNE1 in both bipolar disorder and recurrent major depression. Molecular Psychiatry 18 , pp. 614-617. 10.1038/mp.2012.48

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Genome-wide association studies (GWAS) have identified a number of loci that have strong support for their association with bipolar disorder (BD). The Psychiatric Genome-Wide Association Study (GWAS) Consortium Bipolar Disorder Working Group (PGC-BD) meta-analysis of BD GWAS data sets and replication samples identified evidence (P=6.7 × 10−7, odds ratio (OR)=1.147) of association with the risk of BD at the polymorphism rs9371601 within SYNE1, a gene which encodes nesprin-1. Here we have tested this polymorphism in an independent BD case (n=1527) and control (n=1579) samples, and find evidence for association (P=0.0095) with similar effect sizes to those previously observed in BD (allelic OR=1.148). In a combined (meta) analysis of PGC-BD data (both primary and replication data) and our independent BD samples, we found genome-wide significant evidence for association (P=2.9 × 10−8, OR=1.104). We have also examined the polymorphism in our recurrent unipolar depression cases (n=1159) and control (n=2592) sample, and found that the risk allele was associated with risk for recurrent major depression (P=0.032, OR=1.118). Our findings add to the evidence that association at this locus influences susceptibility to bipolar and unipolar mood disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: SYNE1, bipolar disorder, unipolar depression, genetics, rs9371601
Publisher: Nature Publishing Group
ISSN: 1359-4184
Last Modified: 09 Nov 2022 07:52

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