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Levels of circulating endothelial cells and colony-forming units are influenced by age and dyslipidemia

Fabbri-Arrigoni, Francesca I., Clarke, Lindsey, Wang, Guosu, Charakida, Marietta, Ellins, Elizabeth Anne ORCID:, Halliday, Neil, Brogan, Paul A., Deanfield, John E., Halcox, Julian P. J. and Klein, Nigel 2012. Levels of circulating endothelial cells and colony-forming units are influenced by age and dyslipidemia. Pediatric Research 72 (3) , pp. 299-304. 10.1038/pr.2012.76

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Background: The balance between endothelial injury and repair in childhood is poorly understood. We examined this relationship in healthy children, in adults, and in children with familial hypercholesterolemia (FH). Methods: Circulating endothelial cells (CECs) were measured as a marker of vascular injury, with vascular repair assessed by counting colony-forming units (CFUs), also known as endothelial progenitor cells. Results: CEC number increased with age. Children with FH had elevated CECs as compared with healthy children, with similar levels numerically to those found in healthy adults. CFU numbers were higher in healthy children than either healthy adults or children with FH. Endothelium-dependent vascular function, measured by flow-mediated dilatations, was positively associated with CFU number, even after adjustment for confounding risk variables. Conclusion: Levels of CECs increase and CFUs decrease with age. In childhood, before the onset of clinically detectable cardiovascular dysfunction, children with a major risk factor for atherosclerotic disease have levels of these indexes of vascular injury and repair approaching those seen in adults.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RJ Pediatrics
Publisher: Nature Publishing Group
ISSN: 0031-3998
Last Modified: 21 Oct 2022 10:54

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