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Human skin cancer stem cells: a tale of mice and men

Colmont, Chantal Sophie, Harding, Keith Gordon, Piguet, Vincent and Patel, Girish Khandubhai 2012. Human skin cancer stem cells: a tale of mice and men. Experimental Dermatology 21 (8) , pp. 576-580. 10.1111/j.1600-0625.2012.01533.x

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Carcinomas, cancers of epithelial tissues, are the commonest malignancies and cause the greatest cancer mortality worldwide. Among these, the incidence of keratinocyte-derived non-melanoma skin cancers (NMSC), by far the greatest, is increasing rapidly. Yet despite access to tumor tissue, acceptance of human NMSC as a model carcinoma has been hindered by the lack of a reliable xenograft model. Instead, we have relied on the murine two-step carcinogenesis protocol as a reproducible squamous cell carcinoma (SCC) model, but this differs from their human counterpart in cause, site, genetic basis and biological behaviour. By xeno-engraftment of primary human SCC, we were recently successful in demonstrating the presence of primary human SCC cancer stem cells or tumor-initiating cells. These findings once more align the study human SCC as the archetypal carcinoma model. In this review, we describe the evidence for the existence of tumor-initiating cells, with emphasis on skin cancer, limiting our discussions to primary human cancer studies where possible.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RL Dermatology
Uncontrolled Keywords: cancer stem cells, mouse models, skin cancer, squamous cell carcinoma, tumor-initiating cells
Publisher: Wiley-Blackwell
ISSN: 0906-6705
Last Modified: 09 Jul 2022 08:50

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