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Dropout in crossover and longitudinal studies: is complete case so bad?

Matthews, John N. S., Henderson, Robin, Farewell, Daniel, Ho, Weang-Kee and Rodgers, Lauren R. 2014. Dropout in crossover and longitudinal studies: is complete case so bad? Statistical Methods in Medical Research 23 (1) , pp. 60-73. 10.1177/0962280212445838

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We discuss inference for longitudinal clinical trials subject to possibly informative dropout. A selection of available methods is reviewed for the simple case of trials with two timepoints. Using data from two such clinical trials, each with two treatments, we demonstrate that different analysis methods can at times lead to quite different conclusions from the same data. We investigate properties of complete-case estimators for the type of trials considered, with emphasis on interpretation and meaning of parameters. We contrast longitudinal and crossover designs and argue that for crossover studies there are often good reasons to prefer a complete case analysis. More generally, we suggest that there is merit in an approach in which no untestable assumptions are made. Such an approach would combine a dropout analysis, an analysis of complete-case data only, and a careful statement of justified conclusions.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: SAGE Publications
ISSN: 0962-2802
Last Modified: 12 Mar 2019 10:59

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