A randomized feasibility study of a 12-week community-based exercise program for people with Huntington's Disease

Busse, Monica ORCID: https://orcid.org/0000-0002-5331-5909, Quinn, Lori ORCID: https://orcid.org/0000-0002-2982-923X, Hamana, Katy ORCID: https://orcid.org/0000-0001-5213-253X, Jones, Karen, Collett, Jonathan, Playle, Rebecca Anne ORCID: https://orcid.org/0000-0002-2989-1092, Kelly, Mark James ORCID: https://orcid.org/0000-0001-7744-3780, Simpson, Sharon Anne, Backx, Karianne, Wasley, David, Dawes, Helen and Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 2013. A randomized feasibility study of a 12-week community-based exercise program for people with Huntington's Disease. Journal of Neurologic Physical Therapy 37 (4) , pp. 149-158. 10.1097/NPT.0000000000000016

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Abstract

Background and Purpose: The beneficial role of exercise as a treatment approach in Huntington's disease (HD) has support from both preclinical work and small-scale studies; however, there have been no controlled studies of gym-based exercise in people with HD. This phase 2 randomized trial (ISRCTN 59910670) assessed feasibility, safety, acceptability, and benefit of a structured exercise program. Methods: Thirty-one participants (16 men; mean [SD] age = 50.4 [11.4] years) were randomly allocated to intervention (n = 16) or control group (usual care; n = 15). The intervention entailed a weekly supervised gym session of stationary cycling and resistance exercises, and a twice weekly independent home-based walking program. Retention and adherence rates and adverse events were recorded. Acceptability was determined from subjective reports of tolerability and physiological measures recorded during the gym sessions. Assessment of benefit included measures of physical abilities, disease severity, and quality of life (36-Item Short Form Health Survey). Analysis of covariance was used to test outcomes of interest. Results: The retention rate was 81% (9 of the 11 individuals who started the intervention completed it) and of the 9 who completed the program, 7 attended more than 75% (9/12) of the gym sessions. There were no related adverse events and the intervention was well tolerated by most participants. The between-group effect estimate for the Mental Component Summary score of the 36-Item Short Form Health Survey (n = 9; intervention, n = 13; control) was 7 (95% CI: 0.4–13.7) Moderate effect sizes for cognitive outcomes and measures of walking were also observed. Discussion and Conclusions: Observed effect sizes for clinical outcomes suggest the structured exercise program has benefit for persons with HD; larger scale trials are warranted.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Healthcare Sciences Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	Adult; Aged; Blood Pressure; Exercise Therapy; Feasibility Studies; Female; Humans; Huntington Disease; Male; Middle Aged; Quality of Life; Resistance Training; Treatment Outcome; Walking
ISSN:	1557-0576
Funders:	National Instuitute for Social Care and Health, Wales
Last Modified:	09 Aug 2024 13:57
URI:	https://orca.cardiff.ac.uk/id/eprint/43648

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