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Free radical scavenging properties of melanin: interaction of eu- and pheo-melanin models with reducing and oxidising radicals

Rozanowska, Malgorzata Barbara, Sarna, T., Land, E. J. and Truscott, T. G. 1999. Free radical scavenging properties of melanin: interaction of eu- and pheo-melanin models with reducing and oxidising radicals. Free Radical Biology and Medicine 26 (5-6) , pp. 518-525. 10.1016/S0891-5849(98)00234-2

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The human skin and eye melanin is commonly viewed as an efficient photoprotective agent. To elucidate the molecular mechanism of the melanin-dependent photoprotection, we studied the interaction of two synthetic melanins, dopa-melanin and cysteinyldopa-melanin, with a wide range of oxidising and reducing free radicals using the pulse radiolysis technique. We have found that although both types of free radicals could efficiently interact with the synthetic melanins, their radical scavenging properties depended, in a complex way, on the redox potential, the electric charge and the lifetime of the radicals. Repetitive pulsing experiments, in which the free radicals, probing the polymer redox sites, were generated from four different viologens, indicated that the eumelanin model had more reduced than oxidised groups accessible to reaction with the radicals. Although with many radicals studied, melanin interacted via simple one-electron transfer processes, the reaction of both melanins with the strongly oxidising peroxyl radical from carbon tetrachloride, involved radical addition. Our study suggests that the free radical scavenging properties of melanin may be important in the protection of melanotic cells against free radical damage, particularly if the reactive radicals are generated in close proximity to the pigment granules.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Uncontrolled Keywords: Melanin; Antioxidant; Photoprotection; Free radical scavenger; Oxidative stress; Pulse radiolysis; Redox properties
Publisher: Elsevier
ISSN: 0891-5849
Last Modified: 04 Jun 2017 04:45

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