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Carotenoid radical-melanin interactions

Edge, R., Land, E. J., Rozanowska, Malgorzata Barbara, Sarna, T. and Truscott, T. G. 2000. Carotenoid radical-melanin interactions. Journal of Physical Chemistry B 104 (30) , pp. 7193-7196. 10.1021/jp9941561

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The radical cations of five dietary carotenoids have been shown to react with dopamelanin (a model of the black eumelanin) and cysteinyldopamelanin (a model of the red/yellow pheomelanin) in both micellar and homogeneous environments. It is suggested that such repair reactions show previously unidentified protective roles for melanin/carotenoid combinations, especially where the maintenance of the (small) carotenoid concentration is vital to avoid deleterious effects, such as in the retina of the eye.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Additional Information: Correction: Page 7193. Following is the correct Acknowledgment for the article. Acknowledgment. The pulse radiolysis experiments were performed at the Paterson Institute for Cancer Research Free Radical Research Facility, Christie Hospital NHS Trust, Manchester. The facility is supported by the European Commission TMR Programme − Access to Large-Scale Facilities. E.J.L. thanks the Cancer Research Campaign, T.S. and M.R. thank the Polish State Committee for Scientific Research (KBN grant 6 PO4A 062 17 and 4 PO5A 036 15), and R.E. and T.G.T. thank Hoffmann-La Roche for financial support. T.S. and T.G.T thank the Wellcome trust for support. 10.1021/jp012187208/01/2001
Publisher: ASC Publications
ISSN: 1520-6106
Last Modified: 04 Jun 2017 04:45

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