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Subtraction artifacts and frequency (Mis-)alignment in J-difference GABA editing

Evans, Christopher John ORCID:, Puts, Nicolaas, Robson, Siân E., Boy, Frederic, McGonigle, David ORCID:, Sumner, Petroc ORCID:, Singh, Krish Devi ORCID: and Edden, Richard A. E. 2013. Subtraction artifacts and frequency (Mis-)alignment in J-difference GABA editing. Journal of Magnetic Resonance Imaging 38 (4) , pp. 970-975. 10.1002/jmri.23923

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Purpose: To compare the repeatability of γ-aminobutyric acid (GABA) measurements using J-difference editing, before and after spectral realignment—a technique which has previously been demonstrated to improve the quality of J-difference GABA spectra. Materials and Methods: We performed in vivo measurements in three brain regions (occipital, sensorimotor, and dorsolateral prefrontal cortex [DLPFC]), and analyzed these using alternative alignment approaches to evaluate the impact of alignment on repeatability: “Independent alignment” (aligning each subspectrum independently) and “Pairwise alignment” (aligning each on and off subspectrum as a pair) were compared. Results: Pairwise alignment improved the group mean coefficient of variation in all regions; 0.4% in occipital, 1.1% in sensorimotor, and 1.1% in DLPFC. Independent alignment resulted in subtraction artifacts in the majority of cases, and increased the coefficient of variation in the DLPFC by 9.4%. Simulations demonstrate that the GABA quantification error in datasets with high B0 drift, is 4.5% without alignment, but <1% with optimal alignment. Conclusion: Pairwise alignment improves the repeatability of GABA spectroscopy data. However, independently aligning all on and off subspectra can lead to artifacts and worse repeatability when compared with nonaligned data. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Publisher: Wiley
ISSN: 1053-1807
Last Modified: 09 Jun 2024 15:50

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