An international field study of the EORTC QLQ-PR25: a questionnaire for assessing the health-related quality of life of patients with prostate cancer

van Andel, George, Bottomley, Andrew, Fosså, Sophie D., Efficace, Fabio, Coens, Corneel, Guerif, Stephane, Kynaston, Howard ORCID: https://orcid.org/0000-0003-1902-9930, Gontero, Paolo, Thalmann, George, Akdas, Atif, D?Haese, Sven and Aaronson, Neil K. 2008. An international field study of the EORTC QLQ-PR25: a questionnaire for assessing the health-related quality of life of patients with prostate cancer. European Journal of Cancer 44 (16) , pp. 2418-2424. 10.1016/j.ejca.2008.07.030

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Abstract

Aim: To evaluate the psychometrics of the EORTC QLQ-PR25, a questionnaire assessing the health-related quality of life of prostate cancer patients. Methods: The QLQ-PR25 and the QLQ-C30 were administered to 642 prostate cancer patients from 13 countries treated with curative or palliative intent. The QLQ-PR25 assesses urinary, bowel and sexual symptoms and functioning, and the side-effects of hormonal treatment. Results: Five hundred and nine patients were available for the final analysis. Multitrait scaling analyses confirmed the hypothesised scale structure of the QLQ-PR25. Internal consistency reliability was good (coefficient α = 0.70–0.86) for the urinary symptoms and sexual function scales, but lower for the bowel function and side-effects of hormonal treatment scales (α < 0.70). The module discriminated clearly between clinically distinct patient subgroups, and was responsive to changes in health status over time. Conclusion: In general, the QLQ-PR25 demonstrates acceptable psychometric properties and clinical validity. Some caution should be used in interpreting the bowel function and side-effects of hormonal therapy scales; results can be reported at the individual item and scale level.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Prostate cancer; Quality of life; Patient-reported outcome; Questionnaire; Bladder function; Urinary function; Sexuality
Publisher:	Elsevier
ISSN:	0959-8049
Last Modified:	24 Oct 2022 11:33
URI:	https://orca.cardiff.ac.uk/id/eprint/48543

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