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Exposure and harm to combustion-derived particles: Searching for biomarkers

Berube, Kelly Ann, Gushina, Irina, Wlodarczyk, Anna Julia, Prytherch, Zoe Cariad, Jones, Timothy, Karg, Erwin, Sippula, Oli, Harndorf, H., Rabe, R., Streibel, T. and Zimmermann, Ralf 2014. Exposure and harm to combustion-derived particles: Searching for biomarkers. Presented at: European Aerosol Conference 2013, Prague, Czech Republic, 1-6 September 2013.

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The physicochemical properties of size, surface area and presence of transition metals have been implicated as drivers of the oxidative capacity of CDPM. However, the precise role of reactive organic compounds (ROC) in ambient aerosols, present either in the gas phase or the particle phase or in both phases, have not been fully-investigated for their relevance in the induction of the observed adverse health effects. Oxidation of fatty acids linked to the cell membrane phospholipids leads to many metabolites that have been used as markers of the process. Such metabolites have long been considered to be involved in two possibly inter-related processes: cell/tissue damage and signalling. As one approach to resolve the role played by ROCs, their effects on fatty acid and lipid metabolism in human lung tissues will be studied in detail by using the standard biochemical techniques and lipidomics.

Item Type: Conference or Workshop Item (Speech)
Date Type: Completion
Status: Unpublished
Schools: Biosciences
Earth and Environmental Sciences
Subjects: Q Science > QR Microbiology
Related URLs:
Date of First Compliant Deposit: 30 March 2016
Last Modified: 13 Sep 2019 21:41

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