Alteration in oxidative stress and F-actin assembly by incense particles

Chuang, Hsiao-Chi, Jones, Timothy Peter ORCID: https://orcid.org/0000-0002-4466-1260, Chen, Tzu-T and Berube, Kelly Ann ORCID: https://orcid.org/0000-0002-7471-7229 2013. Alteration in oxidative stress and F-actin assembly by incense particles. Presented at: Workshop on Aerosol Emissions from Fossil and Biomass Combustion, Prague, Czech Republic, 27-31 August 2013.

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Abstract

Research has indicated that the smoke from incense combustion contains toxic pollutants, such as particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5), metals and organic components, which have been associated with adverse human health effects. The physicochemistry of incense PM2.5 emitted from the three types of incense joss sticks (A-C) have been outlined in our previous study.1 The physicochemical characterization included particulate and gaseous emissions, as well as the determination of the inorganic compounds. The collected incense PM2.5 consisted of spherical singlets, chains and irregular-shaped aggregates (Figure 1). To understand the effects of oxidative stress in vitro caused by the incense PM2.5, A549 cells were exposed to the PM2.5 (± N-acetyl-L-cysteine, NAC).2 The cells significantly exhibited incense PM2.5 induced intracellular reactive oxygen species (ROS) formation (p<0.05; compared to background (BG) levels in a dose-dependent manner (Figure 2a), and a quadratic time response (Figure 2b). The increased levels of ROS production caused by incense PM2.5 were significantly reduced by the addition of NAC (p<0.05; Figures 2a, 2b), but the levels still persisted, especially at the higher concentrations of the incense PM2.5, when compared to the BG levels (p<0.05).

Item Type:	Conference or Workshop Item (Poster)
Date Type:	Completion
Status:	Unpublished
Schools:	Biosciences Earth and Environmental Sciences
Subjects:	Q Science > QR Microbiology
Related URLs:	Organisation
Date of First Compliant Deposit:	30 March 2016
Last Modified:	11 Dec 2022 09:21
URI:	https://orca.cardiff.ac.uk/id/eprint/51210

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