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Obesity and impairments in chronic obstruction pulmonary disease (COPD)

Gale, Nichola S., Albarrati, Ali, Munnery, Iain C., Munnery, Margaret, Cockcroft, John Ronald and Shale, Dennis 2013. Obesity and impairments in chronic obstruction pulmonary disease (COPD). Presented at: European Respiratory Society Annual Congress 2013, Barcelona, Spain, 7-11 September 2013.

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Background: In patients with COPD, a preserved BMI may improve survival. However, the implications for function and health status have not been fully established. We hypothesised that obese patients would have reduced physical capacity and more impairments than non-obese patients with COPD and comparator subjects. Method: As part of a longitudinal study of co-morbidities in COPD (ARCADE), 400 patients (COPD confirmed with spirometry) and 100 comparator subjects (past or current smokers) free from respiratory disease were assessed. In all subjects, spirometry, BMI, six minute walk distance (6MWD), the Timed Up and Go (TUG) and physical, medical, functional and psychosocial impairments using the Comprehensive Geriatric Assessment (CGA) were determined. Patients also completed the St George’s Respiratory Questionnaire (SGRQ) and were categorised by BMI. Results: Patients and comparators were similar in gender and BMI COPD 28.0(5.5) comparators 28.5(4.6) kg/m2, and had similar proportions across the BMI categories, in both groups a third were obese (>30kg/m2). Lung function differed in patients and controls FEV1% predicted 58(20) and 105(15) respectively (p<0.01), but did not differ across the BMI categories. Patients had reduced 6MWD, increased TUG and CGA than comparators in each BMI category (all p<0.001) and in COPD 6MWD, TUG, CGA and SGRQ differed across the BMI categories (ANOVA p<0.05). Obese patients had reduced 6MWD and greater TUG, SGRQ than patients with BMI 20-29.9 (p<0.001). Conclusion: Obese patients with COPD had reduced physical capacity and more impairments than non obese patients and obese comparators. Optimisation of BMI may improve physical outcomes for patients with COPD.

Item Type: Conference or Workshop Item (Poster)
Date Type: Completion
Status: Unpublished
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
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Last Modified: 11 Sep 2022 07:59

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