Tumour-associated angiogenesis in the development and metastasis of human colorectal cancer

Rmali, Khaled Ali Ramadan 2006. Tumour-associated angiogenesis in the development and metastasis of human colorectal cancer. PhD Thesis, Cardiff University.

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Abstract

The study has further shown that IL-1[Special character omitted] is a potential regulator of TEM-8 expression in tumours and that IL-1[Special character omitted] significantly induced the formation of capillary-like tubules from the HECV cells, accompanied by an increase in TEM-8 expression. Where as, elimination of TEM-8 by way of ribozyme transgene significantly decreased the formation of capillary-like tubules and the mobility of HECV cells. Moreover we have demonstrated that the vW domain together with trans-membrane domain of TEM-8 are the structural domain that are responsible for the tubule forming action of TEM-8, using expression construct in varying cell lines.

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Date of First Compliant Deposit:	30 March 2016
Last Modified:	12 Feb 2016 23:11
URI:	https://orca.cardiff.ac.uk/id/eprint/54099

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