Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors

Famiglini, Valeria, Coluccia, Antonio, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Pelliccia, Sveva, La Regina, Giuseppe and Silvestri, Romano 2013. Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors. Future Medicinal Chemistry 5 (18) , pp. 2141-2156. 10.4155/fmc.13.174

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Abstract

HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent one of the most significant classes of drugs for the treatment of AIDS/HIV infection. Over the past two decades several potent arylsulfone-based HIV-1 NNRTIs and related analogs have been developed. This review provides an essential overview of the structure–activity relationships of the arylsulfone-based HIV-1 NNRTIs. Furthermore, structural information useful for the design and development of new sulfur containing NNRTIs with enhanced antiretroviral activity against HIV-1 wild type and clinically relevant drug resistant HIV-1 mutant strains will be discussed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RS Pharmacy and materia medica
Publisher:	Future Science Ltd
ISSN:	1756-8919
Last Modified:	05 Jan 2024 05:54
URI:	https://orca.cardiff.ac.uk/id/eprint/56810

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