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Mechanism of enhancement of rat brain serotonin synthesis by acute fluoxetine administration

Badawy, Abdulla A. B., Morgan, Christopher J., Bano, Samina, Buckland, Paul Robert and McGuffin, Peter 2002. Mechanism of enhancement of rat brain serotonin synthesis by acute fluoxetine administration. Journal of Neurochemistry 66 (1) , pp. 436-437. 10.1046/j.1471-4159.1996.66010436.x

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Tsuiki et a!. (1995) reported in this Journal that acute intraperitoneal administration of a 30 mg/kg of body weight dose of the specific serotonin [5-hydroxytryptamine (5-HT)11 reuptake inhibitory (SSRI) antidepressant fluoxetine enhances rat brain 5-HT synthesis, as measured by the a-methyl-L-tryptophan autoradiographic method, and suggested that this is in part due to an increase in tryptophan (Trp) availability to the brain. This process is determined by at least three peripheral factors: binding to albumin, competition between Trp and five other amino acids (valine, leucine, isoleucine, phenylalanine, and tyrosine) for the same cerebral uptake mechanism, and activity of the major Trp-degrading enzyme, hepatic Trp pyrrolase (tryptophan 2,3-dioxygenase; EC (for references, see Badawy and Morgan, 1991). Tsuiki et al. (1995) showed that fluoxetine does not influence the concentrations of the Trp competitors, but increases that of Trp itself (by 18% for the total content and 30% for the free fraction). Whether Trp binding to albumin was significantly altered by fluoxetine could not be ascertained from the data given.

Item Type: Article
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
ISSN: 0022-3042
Last Modified: 05 Feb 2020 03:35

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