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Association analysis of the proneurotensin gene and bipolar disorder

Austin, J., Hoogendoorn, Bastiaan ORCID:, Buckland, Paul Robert, Jones, Ian Richard ORCID:, McCandless, F., Williams, Nigel Melville ORCID:, Middle, F., Owen, Michael John ORCID:, Craddock, Nicholas John ORCID: and O'Donovan, Michael Conlon ORCID: 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10 (1) , pp. 51-54. 10.1097/00041444-200010010-00009

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Neurotensin (NT) localizes within dopaminergic neurones in the mesocortical, mesolimbic and nigrostriatal systems, and it is now clear that NT can selectively modulate dopaminergic neurotransmission. It has therefore been proposed that altered NT function might contribute to the pathogenesis of neuropsychiatric disorders in which disordered dopaminergic neurotransmission is suspected. We have previously screened the gene encoding NT in a sample of schizophrenic and bipolar subjects, and identified three sequence variants. These have now been tested for association with bipolar disorder using a case-control sample of unrelated bipolar subjects and matched controls. No evidence for association was found, and our data therefore suggest that sequence variation in this gene does not make an important contribution to susceptibility to bipolar disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: polymorphism; mutation; gene; schizophrenia; bipolar disorder
Publisher: Lippincott Williams & Wilkins
ISSN: 0955-8829
Last Modified: 12 Dec 2022 08:43

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