Psychopathology and cognition in children with 22q11.2 deletion syndrome

Niarchou, Maria ORCID: https://orcid.org/0000-0002-8855-7393, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, van Goozen, Stephanie H. M. ORCID: https://orcid.org/0000-0002-5983-4734, Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X, Tierling, Hayley M., Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862 and van den Bree, Marianne B. M. ORCID: https://orcid.org/0000-0002-4426-3254 2014. Psychopathology and cognition in children with 22q11.2 deletion syndrome. British Journal of Psychiatry 204 (1) , pp. 46-54. 10.1192/bjp.bp.113.132324

Preview

PDF - Published Version Download (388kB) | Preview

Abstract

BACKGROUND: Children with 22q11.2 deletion syndrome (22q11.2DS) have been reported to have high rates of cognitive and psychiatric problems. AIMS: To establish the nature and prevalence of psychiatric disorder and neurocognitive impairment in children with 22q11.2DS and test whether risk of psychopathology is mediated by the children's intellectual impairment. METHOD: Neurocognition and psychopathology were assessed in 80 children with 22q11.2DS (mean age 10.2 years, s.d. = 2.1) and 39 sibling controls (mean age 10.9 years, s.d. = 2.0). RESULTS: More than half (54%) of children with 22q11.2DS met diagnostic criteria for one or more DSM-IV-TR psychiatric disorder. These children had lower IQ (mean 76.8, s.d. = 13.0) than controls (mean 108.6, s.d. = 15.2) (P<0.001) and showed a range of neurocognitive impairments. Increased risk of psychopathology was not mediated by intellectual impairment. CONCLUSIONS: 22q11.2DS is not related to a specific psychiatric phenotype in children. Moreover, the deletion has largely independent effects on IQ and risk of psychopathology, indicating that psychopathology in 22q11.2DS is not a non-specific consequence of generalised cognitive impairment.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Psychology Neuroscience and Mental Health Research Institute (NMHRI) MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Cambridge University Press
ISSN:	0007-1250
Funders:	Wellcome Trust
Date of First Compliant Deposit:	30 March 2016
Last Modified:	05 May 2023 23:11
URI:	https://orca.cardiff.ac.uk/id/eprint/57778

Citation Data

Cited 54 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item