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Trypophan metabolism in male Sardinian alcohol-preferring (sP)and non-preferning (sNP) rats

Bano, S., Morgan, C. J., Badawy, A. A.-B., Colombo, G., Buckland, Paul Robert, McGuffin, P., Fadda, F. and Gessa, G. L. 1998. Trypophan metabolism in male Sardinian alcohol-preferring (sP)and non-preferning (sNP) rats. Alcohol and Alcoholism 33 (3) , pp. 220-225. 10.1093/oxfordjournals.alcalc.a008385

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Parameters of tryptophan (Trp) and related metabolism were compared in male Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats. Liver Trp pyrrolase activity was 38–58% higher in sP than in sNP rats, and this was associated with a greater expression of the enzyme mRNA as measured by multiprobe oligonucleotide solution hybridization. Moderately (about 10–19%), but significantly, lower concentrations of free serum, total serum, and brain Trp were also observed in sP compared with sNP rats. Concentrations of whole brain 5-hydroxytryptamine (5-HT) and its major metabolite 5-hydroxyindol-3-yl-acetic acid (5-HIAA) were, however, 14–21% higher in sP rats. Serum corticosterone concentration was 18% higher in sP rats. We conclude that alcohol preference in Sardinian rats is associated with increased liver Trp pyrrolase activity and mRNA expression leading to a decrease in Trp availability to the brain. Although a simple serotonin deficiency could not be demonstrated in the whole brain, the possibility could not be ruled Out that a deficiency may be present in discrete areas of the brain of the sP rat.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Oxford University Press
ISSN: 0735-0414
Last Modified: 05 Feb 2020 03:39

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