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Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis

Younes, Laurent, Ratnanather, J. Tilak, Brown, Timothy, Aylward, Elizabeth, Nopoulos, Peg, Johnson, Hans, Magnotta, Vincent A., Paulsen, Jane S., Margolis, Russell L., Albin, Roger L., Miller, Michael I., Ross, Christopher A., Hunt, Sarah and Rosser, Anne ORCID: 2014. Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis. Human Brain Mapping 35 (3) , pp. 792-809. 10.1002/hbm.22214

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Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through “Large Deformation Diffeomorphic Metric Mapping” of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information: Sarah Hunt and Anne Rosser are listed at the end of the article as members of the PREDICT-HD Investigators and Coordinators.
Publisher: Wiley-Blackwell
ISSN: 1065-9471
Last Modified: 25 Oct 2022 09:20

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