Prospective analysis of patient-reported late toxicity following pelvic radiotherapy for gynaecological cancer

Barraclough, Lisa H., Routledge, Jacqueline A., Farnell, Damian J. J. ORCID: https://orcid.org/0000-0003-0662-1927, Burns, Meriel P., Swindell, Ric, Livsey, Jacqueline E. and Davidson, Susan E. 2012. Prospective analysis of patient-reported late toxicity following pelvic radiotherapy for gynaecological cancer. Radiotherapy and Oncology 103 (3) , pp. 327-332. 10.1016/j.radonc.2012.04.018

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Abstract

Background and purpose: As late radiotherapy toxicity impacts negatively on the quality-of-life of cancer survivors and is often under reported, a study was set up to prospectively collect patient-reported data in an unselected series of patients with gynaecological malignancy. Aim 1 – To provide 3 year results for the longitudinal study. Aim 2 – To improve the questionnaire used to collect data by identifying redundant items and modifying for use to collect Common Terminology Criteria for Adverse Events (CTCAE) data. Material and methods: Aim 1 – Patient reported outcome data were collected prospectively by 226 patients before and up to 3 years following radiotherapy for gynaecological cancer using a questionnaire developed to collect LENT subjective data. Aim 2 – A factor analysis was performed to identify which questions gave the most and least information. Results: Aim 1 – Faecal urgency and incontinence (all grades) peaked at 79% and 24%, respectively at 1 year then settled to 69% and 18% at 3 years, respectively. Urinary urgency (all grades) increased with time and was described in 75% at 3 years. Other symptoms reported at 3 years include diarrhoea in 12%, urinary incontinence in 27% and vaginal dryness in 29%. A third of patients did not feel their sex life had changed following treatment, while a quarter felt that it had. Aim 2 – some questions overlapped and others were non-specific. The questionnaire has subsequently been altered. Conclusions: The extent of late toxicity is substantial. This detailed information is important for both patients and clinicians in terms of treatment decisions and follow-up care. The LENT questionnaire provides a feasible tool for capture of this information in the clinic.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Publisher:	Elsevier
ISSN:	0167-8140
Last Modified:	04 Jan 2024 08:39
URI:	https://orca.cardiff.ac.uk/id/eprint/59359

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