Potent antimicrobial activity of bone cement encapsulating silver nanoparticles capped with oleic acid

Prokopovich, Polina ORCID: https://orcid.org/0000-0002-5700-9570, Kobrick, Mathias, Brousseau, Emmanuel Bruno Jean Paul ORCID: https://orcid.org/0000-0003-2728-3189 and Perni, Stefano 2015. Potent antimicrobial activity of bone cement encapsulating silver nanoparticles capped with oleic acid. Journal of Biomedical Materials Research: Part B - Applied Biomaterials 103 (2) , pp. 273-281. 10.1002/jbm.b.33196

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Abstract

Bone cement is widely used in surgical treatments for the fixation for orthopaedic devices. Subsequently, 2–3% of patients undergoing these procedures develop infections that are both a major health risk for patients and a cost for the health service providers; this is also aggravated by the fact that antibiotics are losing efficacy because of the rising resistance of microorganisms to these substances. In this study, oleic acid capped silver nanoparticles (NP) were encapsulated into Poly(methyl methacrylate) (PMMA)-based bone cement samples at various ratios. Antimicrobial activity against Methicillin Resistant Staphylococcus aureus, S. aureus, Staphylococcus epidermidis, Acinetobacter baumannii was exhibited at NP concentrations as low as 0.05% (w/w). Furthermore, the mechanical properties and cytotoxicity of the bone cement containing these NP were assessed to guarantee that such material is safe to be used in orthopaedic surgical practice.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Engineering Pharmacy
Subjects:	T Technology > TA Engineering (General). Civil engineering (General)
Uncontrolled Keywords:	Bone cement; antimicrobial; silver nanoparticles; nanoindentation; PMMA.
Publisher:	Wiley
ISSN:	1552-4981
Funders:	ARUK
Date of First Compliant Deposit:	30 March 2016
Last Modified:	14 May 2023 18:51
URI:	https://orca.cardiff.ac.uk/id/eprint/59741

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