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A randomised feasibility study of a 12-week exercise programme in Huntington’s disease (HD)

Busse, Monica, Quinn, Lori, Hamana, Katy, Jones, Karen, Collett, Johnny, Playle, Rebecca, Kelly, Mark, Backz, Karianne, Dawes, Helen and Rosser, Anne 2012. A randomised feasibility study of a 12-week exercise programme in Huntington’s disease (HD). Journal of Neurology, Neurosurgery & Psychiatry 83 , A58-A59. 10.1136/jnnp-2012-303524.182

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Background: This multi-centre controlled study [ISRCTN 59910670] evaluated a 12 week exercise programme in mid stage HD in terms of adherence and potential benefit. Methods: 31 subjects (16 male) [mean (SD) age 50.4 (11.4) years and disease burden score (DBS) 438 (129)] were randomly allocated to intervention (n=16) or control (usual care) (n=15). Mean (SD) total functional capacity scores at baseline were 8.4 (2.6) and 8.9 (3.1) and mean (SD) Unified Huntington’s Disease Rating scale total motor scores (UHDRS TMS) were 32.4 (15.5) and 35.2(20.5) at baseline in the intervention and control respectively. The intervention was a weekly gym session and self-directed walking. Blinded assessments were conducted on a range of outcomes including the UHDRS modified motor score (UHDRSmMS), 30 second chair stand test (CST) and 6 minute walk test. Results: Loss to follow up was greater in those allocated to the intervention group (n=7; 5 never started the intervention) than those in the control (n=2). Median (range) gym attendance (n=9) was 9 (2-12) and mean (SD) weekly walking minutes was 247.5 (239.1). There were no related adverse events. No significant differences were seen at follow-up (controlling for baseline age, gender, DBS and physical activity scores) on the UHDRSmMS (difference between groups adjusted for baseline scores 3.8 95% CI [-0.7, 8.3]); CST (1.28, 95% CI [-1.2, 3.8]) & 6 minute walk (27.2 95% CI [-2.8, 57.2]). Conclusion: Clinical benefit is not clearly demonstrable in this small study, however it is encouraging that there were no related adverse events and that good gym attendance rates were achieved. Data gathered in this study can inform planning of future trials of exercise interventions in HD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Healthcare Sciences
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > RZ Other systems of medicine
Publisher: BMJ Publishing Group
ISSN: 0022-3050
Funders: National Institute for Social Care and Health Research, Wales
Last Modified: 12 Feb 2022 11:16

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