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Predictive value of IL-18 and SC5b-9 for neurocognitive dysfunction after cardiopulmonary bypass

Kumar, R. A., Cann, Clare, Hall, Judith Elizabeth ORCID:, Sudheer, Potteth and Wilkes, A. R. 2007. Predictive value of IL-18 and SC5b-9 for neurocognitive dysfunction after cardiopulmonary bypass. British Journal of Anaesthesia 98 (3) , pp. 317-322. 10.1093/bja/ael366

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Background Neurological injury after cardiopulmonary bypass (CPB) continues to be a major problem after cardiac surgery. The aim of this study was to investigate the predictive value of Interleukin-18 (IL-18) and SC5b-9 as biochemical markers of neurocognitive dysfunction after cardiac surgery. Methods A total of 30 patients undergoing elective cardiac surgery using CPB were recruited. Blood samples were obtained for IL-18 and SC5b-9 concentrations before induction, 24, 48, 72, 96 and 120 h post-CPB and 6 weeks after operation. In addition, patients underwent a standard battery of neuropsychometric tests before operation and at day 5 and 6 weeks after operation. Results Serum concentration of IL-18, but not SC5b-9, was significantly different between patients with and without neurocognitive dysfunction; serum IL-18 concentration significantly increased in patients with neurocognitive dysfunction (P = 0.018). Neurological outcome was significantly dependent on peak difference in IL-18 concentration at day 5 (P = 0.033), but not on peak difference in SC5b-9 concentration (P = 0.16). Eight patients had neurocognitive dysfunction at day 5 and three had neurocognitive dysfunction at 6 weeks. In a very small number of patients, no significant association was demonstrated between IL-18 or SC5b-9 concentrations and neurocognitive dysfunction at 6 weeks. Conclusions IL-18 has the potential as a useful marker of neurological dysfunction, requiring further investigation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Blood; IL-18; blood; SC5b-9; brain injury; heart; cardiopulmonary bypass; polypeptides; IL-18; polypeptides, SC5b-9
Publisher: Oxford University Press
ISSN: 0007-0912
Last Modified: 13 Mar 2023 15:51

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