Buck, Jackie, Casbard, Angela C. ORCID: https://orcid.org/0000-0001-6241-3052, Llewelyn, Charlotte, Johnson, Tony, Davies, Sally and Williamson, Lorna 2005. Preoperative transfusion in sickle cell disease: a survey of practice in England. European Journal of Haematology 75 (1) , pp. 14-21. 10.1111/j.1600-0609.2005.00412.x |
Abstract
Objectives: To gather data on current preoperative transfusion practice and postoperative complications in sickle cell disease (SCD) as a prelude to a randomised trial. Methods: A prospective one year survey of 114 SCD patients undergoing elective surgery in 31 English hospitals was undertaken. Results: 43%, 39% and 23% of patients, respectively, received no transfusion, top-up and exchange transfusion preoperatively. Overall postoperative complication rates were 18%, 26% and 17%, with HbSC/HbSß+thalassaemia and 71% of obstetric and gynaecology patients were not transfused preoperatively, whereas 59% patients undergoing ENT procedures and 83% of hip replacements had top-up and exchange transfusions respectively. Multivariable logistic regression analysis revealed that having moderate/high risk procedures was a predictor of postoperative complications (OR 4.9 (95% Cl: 1.3 to 18), P = 0.017) while preoperative transfusion was not (OR 1.7, (95% Cl: 0.5 to 6), P = 0.41). Conclusion: The lack of clear benefit of transfusion confirms the need for a randomised controlled trial of transfusion vs. no transfusion in patients with HbSS and HbSß0thalassaemia.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > RC Internal medicine |
Uncontrolled Keywords: | sickle cell disease; blood transfusion; preoperative; survey; postoperative complications |
Publisher: | Wiley-Blackwell |
ISSN: | 0902-4441 |
Last Modified: | 25 Oct 2022 09:45 |
URI: | https://orca.cardiff.ac.uk/id/eprint/59896 |
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