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Emerging cystic fibrosis pathogens and the microbiome

Mahenthiralingam, Eshwar ORCID: 2014. Emerging cystic fibrosis pathogens and the microbiome. Paediatric Respiratory Reviews 15 (Supp 1) , pp. 13-15. 10.1016/j.prrv.2014.04.006

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Cystic fibrosis (CF) respiratory infection is characterised by the presence of typical human bacterial pathogens such as Pseudomonas aeruginosa, Haemophilus influenzae and Staphylococcus aureus. Less typical pathogens such as Burkholderia, Stenotrophomonas, Achromobacter, Pandorea and Ralstonia have emerged as problematic infections which are largely unique to people with CF. Using molecular methods, two groups of anaerobic bacteria Prevotella species and the Streptococcus milleri group have also recently been shown to be highly prevalent in CF sputum. Collectively, the diversity of microorganisms present in respiratory specimens has been designated the CF microbiome. The challenges posed by emerging CF pathogens and a microbiome-based view of CF infection are discussed in terms of their impact on clinical outcome, diagnosis and therapy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: Cystic fibrosis; Emerging pathogen; Burkholderia; Stenotrophomonas; Achromobacter; Pandorea; Ralstonia; Prevotella; Streptococcus milleri group; CF microbiome.
Publisher: Elsevier
ISSN: 1526-0550
Last Modified: 25 Oct 2022 09:52

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