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Microbicides - the double-edged sword: environmental toxicity and emerging resistance

Pagès, Jean-Marie, Maillard, Jean Yves ORCID:, Davin-Regli, Anne and Springthorpe, Susan 2012. Microbicides - the double-edged sword: environmental toxicity and emerging resistance. Fraise, Adam P., Maillard, Jean Yves ORCID: and Sattar, Syed A., eds. Russell, Hugo & Ayliffe's: Principles and Practice of Disinfection, Preservation and Sterilization, 5th Edition, Blackwell Publishing, pp. 229-235. (10.1002/9781118425831.ch11)

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The growing use of microbicides, while producing significant health and economic benefits for human society, increases environmental concerns with their associated environmental discharge, and increasing risks associated with development of microbial resistance. Similar mechanisms of transfer of resistance between antibiotics and microbicides have resulted in bacterial co-resistance to both groups of chemicals, and evidence is accumulating to suggest that exposure to sub-lethal microbicide levels might sometimes lead to antibiotic resistance. To- date the amount of microbicides used and discharged in the environment cannot be estimated because of the wide range of applications and the lack ofr reporting. Microbicides have been found in the environment at levels that can generate a substantial selective pressure on microbial microcosms. Until more information is available on the effects of such concentrations on microorganisms, a more prudent use of microbicides isshould be recommended to preserve their efficacy and to minimize any negative effects on humans and the environment.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Publisher: Blackwell Publishing
ISBN: 9781444333251
Last Modified: 25 Oct 2022 10:01

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