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Gross Rearrangement Breakpoint Database (GRaBD)[review]

Abeysinghe, S. S., Stenson, Peter Daniel, Krawczak, M. and Cooper, David Neil ORCID: 2004. Gross Rearrangement Breakpoint Database (GRaBD)[review]. Human Mutation 23 (3) , pp. 219-221. 10.1002/humu.20006

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Translocations and gross gene deletions are an important cause of both cancer and inherited disease. Such DNA rearrangements are nonrandomly distributed in the human genome as a consequence of selection for growth advantage and/or the inherent potential of some DNA sequences to be particularly susceptible to breakage and recombination. The Gross Rearrangement Breakpoint Database (GRaBD; was established primarily for the analysis of the sequence context of translocation and deletion breakpoints in a search for characteristics that might have rendered these sequences prone to rearrangement. GRaBD, which contains 397 germline and somatic DNA breakpoint junction sequences derived from 219 different rearrangements underlying human inherited disease and cancer, is the only comprehensive collection of gross gene rearrangement breakpoint junctions currently available.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Wiley-Blackwell
ISSN: 1059-7794
Last Modified: 25 Oct 2022 10:02

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