Childhood absence epilepsy: genes, channels, neurons and networks

Crunelli, Vincenzo ORCID: https://orcid.org/0000-0001-7154-9752 and Leresche, Nathalie 2002. Childhood absence epilepsy: genes, channels, neurons and networks. Nature Reviews Neuroscience 3 (5) , pp. 371-382. 10.1038/nrn811

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Abstract

Childhood absence epilepsy is an idiopathic, generalized non-convulsive epilepsy with a multifactorial genetic aetiology. Molecular-genetic analyses of affected human families and experimental models, together with neurobiological investigations, have led to important breakthroughs in the identification of candidate genes and loci, and potential pathophysiological mechanisms for this type of epilepsy. Here, we review these results, and compare the human and experimental phenotypes that have been investigated. Continuing efforts and comparisons of this type will help us to elucidate the multigenetic traits and pathophysiology of this form of generalized epilepsy.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > Q Science (General)
Publisher:	Nature Publishing Group
ISSN:	1471-003X
Last Modified:	25 Oct 2022 10:05
URI:	https://orca.cardiff.ac.uk/id/eprint/61098

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