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Pacemaker calcium oscillations in thalamic astrocytes in situ

Parri, H. R. and Crunelli, Vincenzo ORCID: 2001. Pacemaker calcium oscillations in thalamic astrocytes in situ. NeuroReport 12 (18) , pp. 3897-3900. 10.1097/00001756-200112210-00008

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During development, astrocytes in the ventrobasal thalamus display spontaneous intracellular calcium [Ca2+]i oscillations, that can lead to the excitation of adjacent thalamocortical neurons via an NMDA receptor-mediated mechanism. In this study, we show that while astrocytes usually exhibit oscillations of irregular amplitude and frequency, a subset of spontaneously active thalamic astrocytes exhibits rhythmic, i.e. pacemaker, [Ca2+]i oscillations with an average frequency of 0.019 Hz. This frequency of the pacemaker oscillations is close to the modal frequency of the irregularly oscillating astrocytes, suggesting that there is a preferred frequency for astrocytic [Ca2+]i oscillations. If pacemaker [Ca2+]i oscillations underlie excitatory signaling to neurons, the result would be rhythmic activation of thalamocortical neurons and astrocyte-driven synchronized oscillations within neurons of the thalamocortical loop.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Lippincott, Williams & Wilkins
ISSN: 0959-4965
Last Modified: 25 Oct 2022 10:05

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