Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Mechanisms of odor receptor gene choice in Drosophila

Ray, Anandasankar, Van Der Goes Van Naters, Wynand ORCID:, Shiraiwa, Takashi and Carlson, John R. 2007. Mechanisms of odor receptor gene choice in Drosophila. Neuron 53 (3) , pp. 353-369. 10.1016/j.neuron.2006.12.010

Full text not available from this repository.


A remarkable problem in neurobiology is how olfactory receptor neurons (ORNs) select, from among a large odor receptor repertoire, which receptors to express. We use computational algorithms and mutational analysis to define positive and negative regulatory elements that are required for selection of odor receptor (Or) genes in the proper olfactory organ of Drosophila, and we identify an element that is essential for selection in one ORN class. Two odor receptors are coexpressed by virtue of the alternative splicing of a single gene, and we identify dicistronic mRNAs that each encode two receptors. Systematic analysis reveals no evidence for negative feedback regulation, but provides evidence that the choices made by neighboring ORNs of a sensillum are coordinated via the asymmetric segregation of regulatory factors from a common progenitor. We show that receptor gene choice in Drosophilaalso depends on a combinatorial code of transcription factors to generate the receptor-to-neuron map.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
ISSN: 0896-6273
Last Modified: 25 Oct 2022 10:06

Citation Data

Cited 77 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item