Kaiso-deficient mice show resistance to intestinal cancer

Prokhortchouk, Anna, Sansom, Owen J., Selfridge, Jim, Caballero, Isabel M., Salozhin, Sergey, Aithozhina, Dana, Cerchietti, Leandro, Meng, Fan Guo, Augenlicht, Leonard H., Mariadason, John M., Hendrich, Brian, Melnick, Ari, Prokhortchouk, Egor, Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X and Bird, Adrian 2006. Kaiso-deficient mice show resistance to intestinal cancer. Molecular and Cellular Biology 26 (1) , pp. 199-208. 10.1128/MCB.26.1.199-208.2006

Full text not available from this repository.

Abstract

Kaiso is a BTB domain protein that associates with the signaling molecule p120-catenin and binds to the methylated sequence mCGmCG or the nonmethylated sequence CTGCNA to modulate transcription. In Xenopus laevis, xKaiso deficiency leads to embryonic death accompanied by premature gene activation in blastulae and upregulation of the xWnt11 gene. Kaiso has also been proposed to play an essential role in mammalian synapse-specific transcription. We disrupted the Kaiso gene in mice to assess its role in mammalian development. Kaiso-null mice were viable and fertile, with no detectable abnormalities of development or gene expression. However, when crossed with tumor-susceptible ApcMin/+ mice, Kaiso-null mice showed a delayed onset of intestinal tumorigenesis. Kaiso was found to be upregulated in murine intestinal tumors and is expressed in human colon cancers. Our data suggest that Kaiso plays a role in intestinal cancer and may therefore represent a potential target for therapeutic intervention.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General)
Publisher:	American Society for Microbiology
ISSN:	0270-7306
Last Modified:	25 Oct 2022 10:10
URI:	https://orca.cardiff.ac.uk/id/eprint/61348

Citation Data

Cited 127 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item