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Wnt signal transduction: kinase cogs in a nano-machine?

Ding, Yanning and Dale, Trevor Clive ORCID: 2002. Wnt signal transduction: kinase cogs in a nano-machine? Trends in Biochemical Sciences 27 (7) , pp. 327-329. 10.1016/S0968-0004(02)02137-0

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The control of β-catenin levels is vital to the cell. The primary means of regulation is through ubiquitin-mediated degradation. This process is regulated by Wnt signalling and is frequently disrupted in cancer. Three recent papers show that the initial step in marking β-catenin for degradation involves phosphorylation by casein kinase 1. This then allows phosphorylation by glycogen synthase kinase-3, and the recruitment of ubiquitin-ligase components.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Publisher: Elsevier
ISSN: 0968-0004
Funders: CR-UK
Last Modified: 22 Jun 2023 10:01

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