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A possible role for imprinted genes in inbreeding avoidance and dispersal from the natal area in mice

Isles, Anthony Roger ORCID:, Baum, M. J., Ma, D., Szeto, A., Keverne, E. B. and Allen, Nicholas Denby ORCID: 2002. A possible role for imprinted genes in inbreeding avoidance and dispersal from the natal area in mice. Proceedings of the Royal Society B: Biological Sciences 269 (1492) , pp. 665-670. 10.1098/rspb.2001.1911

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The expression of a subset of mammalian genes is subject to parent of origin effects (POE), most of which can be explained by genomic imprinting. Analysis of mutant animals has demonstrated that a number of imprinted genes influence brain development and behaviour. Here we provide evidence for POE on olfactory related behaviour and sensitivity to maternal odour cues. This was investigated by examining the odour preference behaviour of reciprocal cross F1 mice made by embryo transfer to genetically unrelated foster parents. We determined that both adult males and females show an avoidance of female urinary odours of their genetic maternal but not paternal origin. This was found not to be due to any previous exposure to these odours or due to self‐learning, but may be related to direct effects on the olfactory system, as reciprocal F1 males show differential sensitivity to female odour cues. Currently the most robust theory to explain the evolution of imprinting is the conflict hypothesis that focuses on maternal resource allocation to the developing foetus. Kinship considerations are also likely to be important in the selection of imprinted genes and we discuss our findings within this context, suggesting that imprinted genes act directly on the olfactory system to promote post‐weaning dispersal from the natal area.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: Royal Society
ISSN: 0962-8452
Last Modified: 27 Oct 2022 08:25

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