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Freeing the brain from the perineuronal net

Fox, Kevin Dyson ORCID: and Caterson, Bruce ORCID: 2002. Freeing the brain from the perineuronal net. Science 298 (5596) , pp. 1187-1189. 10.1126/science.1079224

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The brains of young mammals are remarkably plastic, but this plasticity is lost in the adult. In their Perspective, Fox and Caterson discuss an intriguing new study (Pizzorusso et al.) that attempts to restore plasticity to the visual cortex of adult rats. The authors of the study were able to restore plasticity after injecting into the adult rat visual cortex an enzyme (chondroitinase ABC) that degrades the extracellular matrix surrounding neurons and blocking axonal extension.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: American Association for the Advancement of Science
ISSN: 0036-8075
Last Modified: 27 Oct 2022 08:27

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