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Neural transplantation in Parkinson's Disease

Dunnett, Stephen Bruce ORCID: and Rosser, Anne Elizabeth ORCID: 2007. Neural transplantation in Parkinson's Disease. Halberstadt, Craig and Emerich, Dwaine, eds. Cellular Transplantation: From Laboratory to Clinic, Amsterdam ; Boston: Elsevier Academic Press, pp. 439-454. (10.1016/B978-012369415-7/50026-0)

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Both animal studies and clinical trials of neural transplantation suggest that embryonic VM cells can survive transplantation, replace lost dopamine innervation in the striatum caused by toxic damage or disease, and have a functional impact on the host sufficient to alleviate many of the symptoms associated with the lesion. On the basis of the animal studies, there are now a series of trials—both open-label and with controlled designs— in Parkinson's disease patients that support the proof of principle that grafts can partially repair the cell loss associated with this disease, and offer clinically significant benefit in alleviating some of the patients' symptoms. However, the clinical trials have highlighted first that not all symptoms are equally responsive to the treatment and the response can vary significantly from patient to patient; and second that the graft procedure can have distinct adverse effects in some patients,in particular, in the form of uncontrolled dyskinesias. The problems as well as the benefits are manifested equally in the animal models, which offer the tools of addressing and resolving the complications now that they have been clearly identified.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Elsevier Academic Press
ISBN: 9780123694157
Last Modified: 27 Oct 2022 08:27

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