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Neural transplantation in Huntington's disease

Rosser, Anne Elizabeth ORCID: and Dunnett, Stephen Bruce ORCID: 2007. Neural transplantation in Huntington's disease. Halberstadt, Craig and Emerich, Dwaine, eds. Cellular Transplantation: From Laboratory to Clinic, Amsterdam; Boston: Elsevier Academic Press, pp. 417-437. (10.1016/B978-012369415-7/50025-9)

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Studies in experimental animals have demonstrated the efficacy of transplanting fetal neural tissues into the adult brain to repair the damage and alleviate motor and cognitive symptoms associated with focal striatal lesions. These studies have provided the basis for initial clinical trials in patients. Due to the relatively long time (commonly 18 to 24 months) required to start seeing the positive effects of grafts, some years remain still before the impact of such a surgery in Huntington's disease can be assessed. Even then, the human fetal-tissue grafts will provide proof of principle only due to limited availability of human fetal tissue. If positive, it will be necessary to identify a reliable, standardizable, and quality controlled source of tissue for this approach to be widely applied. Consequently, there is an active investigation of alternative sources of cells for transplantation, of which the two most promising at present appear to be: expanded neural stem cells or xenografts of fetal striatal tissues. However, significant problems with each remain to be solved, and clinical trials with these alternative sources are not yet warranted.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Elsevier Academic Press
ISBN: 9780123694157
Last Modified: 27 Oct 2022 08:27

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