Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells

Ashby, Michael C., Petersen, Ole Holger ORCID: https://orcid.org/0000-0002-6998-0380 and Tepikin, Alexei V. 2003. Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells. Biochemical Journal 369 (3) , pp. 441-445. 10.1042/BJ20021039

Full text not available from this repository.

Abstract

In pancreatic acinar cells, agonists evoke intracellular Ca2+ transients which are initiated in the apical region of these polarized cells. There are contradictory experimental data concerning Ca2+ release from ryanodine receptors (RyRs) in the apical region. In the present study, we have used low doses of ryanodine to open RyRs leading to the release of Ca2+ from intracellular stores. Ryanodine causes Ca2+ release that is initiated in the apical region of the cell but is dependent upon functional inositol 1,4,5-trisphosphate receptors (IP3Rs). These results suggests that co-ordinated release from co-localized RyRs and IP3Rs underlies the increased sensitivity of the apical region to initiation of intracellular Ca2+ transients.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Systems Immunity Research Institute (SIURI)
Uncontrolled Keywords: calcium wave, exocrine, pancreatic acinar cell, receptor localization, ryanodine receptor
Publisher: Biochemical Society
ISSN: 0264-6021
Last Modified: 27 Oct 2022 08:42
URI: https://orca.cardiff.ac.uk/id/eprint/63147

Citation Data

Cited 18 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item