The gene for Darier's disease maps between D12S78 and D12S79

Parfitt, E., Burge, S., Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610, Roberts, E., McLean, W. H., Weissenbach, J., McGuffin, P. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 1994. The gene for Darier's disease maps between D12S78 and D12S79. Human Molecular Genetics 3 (1) , pp. 35-38. 10.1093/hmg/3.1.35

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Abstract

Darier's disease is a dominantly inherited skin disorder in which there is abnormal adhesion between keratinocytes. We and others have recently mapped the disease gene to chromosome 12q23-q 24.1. In the present study we have established that the disease gene lies between the loci D12S78 and D12S79 which are 12cM apart. We have also obtained direct evidence that the disease is unlikely to result from a mutation in one of the members of the keratin gene cluster on chromosome 12q.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Publisher:	Oxford University Press
ISSN:	0964-6906
Last Modified:	27 Oct 2022 08:50
URI:	https://orca.cardiff.ac.uk/id/eprint/63513

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