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The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology

Heygi, Peter and Petersen, Ole 2013. The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology. In: Nilius, Bernd, Amara, Susan G., Gudermann, Thomas, Jahn, Reinhard, Lill, Roland, Offermanns, Stefan and Petersen, Ole Holger eds. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 165. Cham, Switzerland: Springer Verlag, pp. 1-30. (10.1007/112_2013_14)

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There are many reviews of pancreatic acinar cell function and also of pancreatic duct function, but there is an almost total absence of synthetic reviews bringing the integrated functions of these two vitally and mutually interdependent cells together. This is what we have attempted to do in this chapter. In the first part, we review the normal integrated function of the acinar-ductal system, with particular emphasis on how regulation of one type of cell also influences the other cell type. In the second part, we review a range of pathological processes, particularly those involved in acute pancreatitis (AP), an often-fatal human disease in which the pancreas digests itself, in order to explore how malfunction of one of the cell types adversely affects the function of the other.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > Q Science (General)
Publisher: Springer Verlag
ISBN: 9783319009988
ISSN: 0303-4240
Last Modified: 04 Jun 2017 06:40

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